Abstract
IN PREVIOUS quantitative studies from this laboratory it has been shown that the ovarian response of the non-castrated partner of parabiotic rats is a sensitive and reliable indicatorof the quantity of gonadotropic hormone released into the circulation of the rats by the pituitarygland of the castrated partner. It was demonstrated that crystalline estrone (1), estrin from theamniotic fluid of cattle (2) and testosterone, testosterone propionate and dehydroandrosterone (3)were effective in preventing the hypersecretion of gonadotropic hormone that occurs following castration of either male or female rats. When progressively greater quantities of the gonadal hormoneswere injected into the castrated partner the size of the ovaries of the normal partner was progressively decreased. If sufficient hormone was injected the ovaries were no larger than those of non-castrated controls.
Published Version
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