Abstract
The effect of removal of the thyroids, and of calcitonin (CT) infusion, on urinary calcium values was studied in the rat. Calcium infusion into thyroidectomized rats bearing functional parathyroid transplants (PTT-TX) resulted in urine calcium values 10–20-fold greater than those following similar infusion to normal rats or to PTT-TX rats also infused with CT. Daily renal excretion of calcium was determined in PTT-TX rats fed normal or restricted amounts of laboratory rat chow, and compared to that of normal rats and of rats with intact thyroid glands and transplanted parathyroid glands. The absence of the thyroid glands resulted in a daily renal excretion of calcium which was approximately 0.5 mg greater than control values. Injection of salmon CT into PTT-TX rats during the period of active feeding reduced the urinary calcium excretion to normal for the first 24 h collection period. Continued daily injections of this hormone, however, reversed this effect, and by the third day, caused an increased renal...
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