Abstract
Abstract: The fractional removal rate of intravenously injected fat emulsions prepared with various emulsifiers, was studied in rabbits. The emulsions were made with soya bean oil and addition of egg yolk phosphatides, acetylated monoglycerides or polyoxypropylene‐polyoxyethylene condensates (Pluronic). In some studies lipid soluble drugs were also added to the emulsions. The fractional removal rates of the emulsions from the blood stream were determined by means of an intravenous fat tolerance test. Addition of phosphatides slightly promoted the elimination of the fat emulsions, whereas the surface active agent Pluronic F 108 considerably impaired the fractional removal rate. Addition of cyclandelate or nitroglycerin increased the fractional elimination rate, whereas diazepam and chlorprozamine had the opposite effect. The half‐life of secobarbital in plasma was unaffected whether administered as emulsion or water solution, but the half‐life of thiopental was slightly longer when given as an emulsion. The pharmacological effect of barbiturates measured as duration of sleep in mice was not affected whether these agents were dissolved in slowly or rapidly eliminated emulsions. The results support the concept that the emulsifying agent is of major importance for the fractional removal rate of the emulsion from the blood stream, and further that the pharmacological effect of barbiturates dissolved in emulsions of different types is not related to the removal rate of the emulsion particles.
Published Version
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