Abstract
The present study aims at evaluation mechanisms of natural plant eleutheroside extracts for ameliorating the blood lipid and blood glucose. The eleutherosides derived from the roots of eleutheroccus senticosus and is purported to behave as an “adaptogen”, we assessed effects of eleutheroside at doses of 3.6, 7.2 and 14.4 g/(kg day) on SD rats injected daily with D-gal (50 mg/(kg day)). Eleutheroside-fed rats showed higher the level HDL-C, decrease the level of HCT, TG, TC, LDL-C compared with D-gal-treated rats. We further examined the mechanisms involved in effects of 3.63.6, 7.2 and 14.4 g/(kg day) on rat blood. In summary, eleutheroside significantly increased Superoxide Dismutase (SOD) activity and decreased the Malondialdehyde (MDA) level.
Highlights
Plant extracts provide a potential source through which novel anti-inflammatory compounds may be identified (Clardy and Walsh, 2004)
We explored whether Eleutheroside has a protective effect against D-galinduced response in rat blood glucose and blood lipid
Blood lipid and blood glucose: From Table 2, we can know that concentration of CHO, TG, LDL, HDL in model group is very outstanding significant; compared with model group, concentration of CHO, TG, LDL, HDL in High-concentration group, TG and HLD in Low-concentration group, CHO, LDL, HD in Mediumconcentration group is significant, concentration of TG is significant rather than GLU; compared with different concentration groups, concentration of CHO in Low-concentration group and High-concentration group is very outstanding significant, concentration of TG in low, high concentration groups and medium, high concentration groups is significant, concentration of LDL in low, huge concentration groups and medium, high concentration groups is significant, besides, there is no differences in others
Summary
Plant extracts provide a potential source through which novel anti-inflammatory compounds may be identified (Clardy and Walsh, 2004). Acanthopanax is a widely used herbal product in China, other Asian countries and the United States. The eleutherosides derived from the roots of eleutheroccus senticosus and is purported to behave as an “adaptogen”, a class of herbal medications that confer resistance to the effects of stress (Gaffney et al, 2001) It have been given the most attention and are believed responsible for the proposed adaptogenic activity. Appearing no report about eleutheroside to impacts of blood glucose and blood lipid. We explored whether Eleutheroside has a protective effect against D-galinduced response in rat blood glucose and blood lipid. We further investigated the potential mechanism underlying its action
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