Abstract
ABSTRACT Introduction: Determination of lipid profile includes triglycerides (TG), total cholesterol and fractions as high-density lipoprotein cholesterol (HDL-c) and low-density lipoprotein cholesterol (LDL-c). These parameters are valuable in the risk assessment of developing cardiovascular disease. However, some pre-analytical factors, such as the fasting state, may interfere with the results of these tests. Objective: The aim of this study was to evaluate differences on lipid profile measurements in blood samples collected at different fasting periods in men and women with or without a diagnosis of hypercholesterolemia. Methods: Fifty volunteers of both sexes, aged between 22 and 86 years, were evaluated. Sociodemographic data and two blood samples were collected, one after 12 hours fast and another during postprandial period, with subsequent measurement of total cholesterol, HDL-c, LDL-c and TG. Results: Comparing the values of the lipid profile obtained in the two collections, it was observed that the total cholesterol and HDL-c did not present significant differences among the evaluated subjects. On the other hand, LDL-c and TG showed significant higher values on postprandial samples, preferably in male group. Conclusion: These data suggest that TG and LDL-c levels are the fractions with greater susceptibility to variations when they are collected without prior fasting.
Highlights
Determination of lipid profile includes triglycerides (TG), total cholesterol and fractions as high-density lipoprotein cholesterol (HDL-c) and low-density lipoprotein cholesterol (LDL-c)
Due to remaining controversies regarding the measures of the lipid profile in postprandial and fasting state, this study aimed to evaluate if there are significant differences in the lipid profile levels of blood samples collected in different periods of fasting from men and women with or without diagnosis of hypercholesterolemia
This project was submitted to the Research Ethics Committee (REC) of the Universidade do Oeste de Santa Catarina (Unoesc) and approved under consubstantiated opinion no. 2.578.688
Summary
Determination of lipid profile includes triglycerides (TG), total cholesterol and fractions as high-density lipoprotein cholesterol (HDL-c) and low-density lipoprotein cholesterol (LDL-c). Determination of the routine lipid profile, including triglycerides (TG), total cholesterol and fractions of low-density lipoprotein cholesterol (LDL-c) and cholesterol and high-density lipoprotein cholesterol (HDL-c), has been performed in the laboratory of clinical analyzes in samples of blood collected after fasting-fed or at least 8 hours fast(3, 4). The set of these results added to the behavioral and nutritional genetic assessment of the subject can predict the risk for the development of chronic cardiovascular diseases(5-8). The TG increase impacts on the calculation of the LDL-c fraction when the Friedewald equation is used(9)
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