The influence of continuous blood purification on the intra-abdominal pressure and the gastrointestinal dysfunction of intra-abdominal hypertension

Abstract

Objective To study the influence of continuous blood purification(CBP) on the intra-abdominal pressure(IAP) and the gastrointestinal dysfunction of intra-abdominal hypertension(IAH). Methods 80 patients with IAH were selected and divided into observation group and control group(n=40) according to random number table method.The observation group was given 3d CBP therapy.The control group was given conventional treatment.The mean arterial pressure(MAP), IAP and abdominal perfusion pressure(APP) were detected.The number of gastrointestinal symptoms was observed, sequential organ failure score(SOFA score) was used to assess the organ function of the two groups before and after treatment. Results The MAP, IAP, APP, SOFA score of the two groups before treatment had no statistically significant differences(P>0.05). The MAP of the two groups after treatment[(88.46±8.93)mmHg vs.(87.76±8.04)mmHg]had no statistically significant difference(P>0.05). The IAP[(9.02±1.06)mmHg]and SOFA score[(1.32±0.45)]of the observation group after treatment were significantly lower, the APP [(85.34±7.59)mmHg] was obviously higher than before treatment and the control group[(19.54±4.23)mmHg, (5.24±2.05)points, (70.76±6.43)mmHg], the differences were statistically significant(t=3.575, 2.855, 3.274, 3.563, 3.114, 3.782, all P 0.05). The number of gastrointestinal symptoms of the observation group after treatment [(6.54±2.24)times] was obviously lower than before treatment and the control group [(15.45±4.43)times], the difference was statistically significant(t=3.022, P 0.05). Conclusion CBP could significantly reduce the IPA of the patients with IAH, raise the APP, improve gastrointestinal perfusion, reduce gastrointestinal symptoms, has positive significance to improve the gastrointestinal dysfunction. Key words: Hemofiltration; Pressure; Gastrointestinal motility