The influence of bisphosphonate on bone mineral density after total knee arthroplasty: A Randomised Controlled Trial

Abstract

PurposeThe effect of bisphosphonate on postoperative bone mineral density (BMD) is rarely reported. In the present study, the BMD change in ipsilateral hip with and without application of bisphosphonate after primary total knee arthroplasty (TKA) was evaluated. Methods and analysisSixty-eight patients undergone TKA due to severe osteoarthritis were enrolled in this study. According to the application of bisphosphonate, the patients were divided into treatment group and control group. The BMD of ipsilateral hip was measured preoperatively and at the 3rd, 6th,12th and 24th month after surgery. Independent t-test was conducted to compare BMD difference between two groups preoperatively and paired t-test was conducted to compare BMD at each time point. The significant difference was considered at P < 0.05. ResultsNo statistical difference of preoperative BMD in femoral neck, wards triangle, greater trochanter and proximal femur between two groups was detected. BMD in all ranges of interest (ROIs) in the control group reached the lowest level at the 12th month after surgery and increased slightly at the 24th month after surgery. The BMD in all ROIs in the treatment group revealed a slight fluctuation around the baseline level. ConclusionThe application of bisphosphonate after TKA contributes to the BMD postoperatively. Bisphosphonate is helpful in reducing complications caused by osteoporosis after TKA as well as the recovery of patients. Therefore, patients can benefit from the application of bisphosphonate.