Abstract
The collagen and mucopolysaccharide content of aortic intima has been studied in relation to age, type of atherosclerotic lesion and lipid. In lesion-free intima collagen shows a slight tendency to rise and mucopolysaccharide to fall with increasing age, but neither change is statistically significant. Mucopolysaccharide increases by a small but significant amount in fatty streaks and nodules (P<0.01), decreases slightly in non-calcified fibrous plaques (P = 0.05) and falls steeply in calcified plaques. Collagen increases slightly in fatty streaks but rises to 60% of the protein in calcified plaques. No consistent relationship is found between collagen, mucopolysaccharide and lipid in intimal hyperplasias which are believed to be precursors of fibrous plaques. The results do not support the view that increased mucopolysaccharide leads to accumulation of lipid in atheromatous lesions.
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