Abstract
Adiponectin is an adipocyte-secreted hormone and regulates the metabolism of lipid and glucose. We examined the influence of adiponectin G276T gene polymorphism on changes in total or high molecular weight adiponectin levels by exercise training. A randomized parallel-design study (n = 53; 40 women and 13 men; age range, 32 - 65 years) was conducted. Participants were randomly assigned to the exercise (n = 26) or control (n = 27) group and received exercise training for 70 min 2 times per week for 12 weeks and exercise advice at the baseline, respectively. Blood sample were obtained before and after the intervention. The primary outcomes were changes in total adiponectin and high molecular weight adiponectin levels. At the baseline, the participants with and without 276G allele did not differ with the total and high molecular weight adiponectin levels in the entire study population. No significant difference in the change in the total and high molecular weight adiponectin levels between the subjects with the G276G genotype and 276T allele carriers were found. This study provides evidence that the G276T polymorphism of the adiponectin gene is not associated with the magnitude of the effect of twice-weekly exercise training on the total and high molecular weight adiponectin levels.
Highlights
Adiponectin is the most abundantly secreted adipokine [1]
The most important finding in this study is that the change in the total and high molecular weight (HMW) adiponectin levels by twice-weekly exercise training was not associated with adiponectin G276T gene polymorphism
Few reports have investigated the effect of gene polymorphism on exercise-training-induced changes in the total adiponectin levels [13,18]
Summary
Adiponectin is the most abundantly secreted adipokine [1]. It has been reported to play a role in the development of insulin resistance [2], obesity [3], hyperlipidemia [4], type 2 diabetes mellitus [5], and cardiovascular diseases [6]. The adiponectin G276T gene polymorphism has been shown to be associated with type 2 diabetes, insulin resistance, and serum adiponectin levels [11,12]. Huang et al showed that the G276T polymorphism of the adiponectin gene affects of the magnitude of the effects of exercise training on the circulating total adiponectin levels [13]. The influence of adiponectin gene polymorphism on the change in circulating adiponectin level by exercise training has not been well documented. The effects of gene polymorphism on exercise-training-induced changes in the HMW adiponectin levels is still unclear. We examined the effects of adiponectin G276T gene polymorphism on the changes in total or HMW adiponectin levels by twice-. Ando et al / Health 3 (2011) 737-741 weekly exercise training
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
