The Induction of Nevi and Skin Tumors in Pigmented Hairless Mice (HRA, HRII-c/+SKH) by 9,10-Dimethyl-1,2-Benzanthracene and Ultraviolet Radiation

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Skin tumors, including malignant melanomas, squamous cell carcinomas and basal cell carcinomas, are the most frequently occurring tumors in man. Squamous cell carcinomas are readily induced in mice by topical administration of chemical carcinogens (e.g., 9,10-dimethyl-1,2-benzanthracene, DMBA) or exposure to ultraviolet radiation (UVR). Mammalian models for the induction of malignant melanomas and basal cell carcinomas are not readily available [1–12]. We investigated the occurrences of melanotic lesions and non-melanotic skin tumors in pigmented hairless mice using a variety of treatment regimens with topical DMBA administration and UVR exposure.