Abstract
Background: Occupational air pollution exposure in textiles industry which irritates the respiration system triggers the disturbance of the nasal mucosa.IL-6 is produced by monocytes and macrophages as a response for tissue damage. SOD-3 is extracellular enzymes protected the tissue from free radical and chronic inflammation. Objectives: To know if the occupational air pollution affects the increasing of IL-6 and SOD-3 level on nasal wash. Methods: this study used an analytical observational design with cross-sectional method. It was conducted on 40 male workers of garment industry in Bawen, Semarang,Indonesia. Divided into two groups: the dyeing and sizing area with 20 workers each group. The workers exposed to the occupational air pollutant for 5 years or more. The aquabidest will be injected to subject’s nosetril using the 20cc spuit. The nasal wash’s sample on the 1.5ml eppendorf tubes will be examined using ELISA method to determine the IL-6 and SOD-3 level. The occupational air pollution indicators will be measured by Envilab Semarang. Findings : The measurements of direct PM10 and PM2.5 in dyeing and sizing area were higher than the regulatory limit. There was a significant difference in the IL-6 level in dyeing and sizing area (p=0,010). There was no significant difference in the SOD-3 level in dyeing and sizing area (p=0,443). There was a positive, moderate and significant correlation between IL-6 and SOD-3 in dyeing and sizing area (r=0.320). Conclusion: The study concluded that the occupational air pollution especially the PM10 and PM2.5 affects the IL-6 and SOD-3 level in the textile industry workers’ nasal wash. There is a significant correlation between the IL-6 and SOD-3 level in textile industry workers at dyeing and sizing area. There is a difference in the IL-6 level in dyeing and sizing area. But there is no significant in the SOD-3 level in dyeing and sizing area. The higher occupational air pollution inhaled will be compensated with the higher expression of IL-6 and SOD-3. The higher exposure of PM2.5 in the dyeing area results in the higher level of IL-6 and SOD-3. Keywords: Interleukin 6; superoxide dismutase 3; occupational air pollution;ELISA
Highlights
Occupational air pollution exposure in textiles industry which irritates the respiration system triggers the disturbance of the nasal mucosa
The results showed that in the dyeing and sizing area, the direct PM10 and PM2.5 measurements is above the regulatory limit standard for 24-hour
Occupational air pollutant may result in adverse health effect in the exposed textile industries workers, even if it is in a small amount and does not exceed the occupational exposure limits
Summary
Occupational air pollution exposure in textiles industry which irritates the respiration system triggers the disturbance of the nasal mucosa. SOD-3 is extracellular enzymes protected the tissue from free radical and chronic inflammation. There was no significant difference in the SOD-3 level in dyeing and sizing area (p=0,443). Conclusion: The study concluded that the occupational air pollution especially the PM10 and PM2.5 affects the IL-6 and SOD-3 level in the textile industry workers’ nasal wash. There is a significant correlation between the IL6 and SOD-3 level in textile industry workers at dyeing and sizing area. Occupational air pollutant in textile industry irritates the respiration system which in turn causes the disturbance of the nasal mucosa [1]. The distribution of SOD-3 in the extracellular compartment indicates that the enzyme is protecting against free radical damage and chronic inflammation. In the state of stress oxidative, the production of free radical damages the extracellular matrix [5,6]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
