Abstract
Objective To evaluate the changes of CD4~+CD25~+T cells in peripheral blood of liver cancer patients,and observe the relationship between CD4~+CD25~+regulatory T cell and the clinicopathologic characters. Methods 37 patients with liver cancer,30 patients with hepatic cirrhosis were included in this study. The proportion of CD4~+CD25~+T cells population in total T cells was evaluated by flow cytometry analysis. The cytokine production (TGF-βl) was measured by ELISA. Results The population of CD4~+CD25~+T cells in peripheral blood from hepatic carcinoma patients was significantly higher in comparison with that in hepatic cirrhosis patients (P<0. 05 ). The CD4~+CD25~+T cells population in liver cancer patients was positively correlated with the cancer size and TGF-β1 level (P<0.05 ). Conclusion CD4~+CD25~+regulatory T cell is prevalent in liver cancer. It may be responsible for immune suppression in liver cancer patients. Key words: CD4~+CD25~+regulatory T cell; Hepatic carcinoma; Flow cytometry; Immunosuppression
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