Abstract
SummaryThe aim of this study was to examine the effect of ionic content of immersion medium on the degradation of PLGA based composite membranes intended for guided bone regeneration applications. The in vitro degradation of pure poly(lactic‐co‐glycolic acid) (PLGA) membranes and PLGA/nanoapatite (NAp)/lauric acid (LA) graded composite membranes was studied for 12 weeks in two types of immersion mediums, i.e., phosphate buffer saline (PBS) and simulated body fluid (SBF) at 37°C with a controlled pH condition at 7.4. A comparative immersion study between PBS and SBF showed weight loss in PBS soaked composite membranes whereas a continuous weight gain was observed in SBF soaked membranes due to induction of calcium phosphate minerals as evidenced in the scanning electron microscopy (SEM) analysis. The apatite mineralisation on SBF soaked membrane surfaces reflects its excellent in vitro bone bioactivity. The new apatite mineralisation on composite membrane surfaces is referred to the possible positive impact in vivo for new bone regeneration. Hence, it can be concluded that SBF is a closely mimicking physiological environment that enables one to fine‐tune the genuine degradation behavior of membranes compared to PBS for potential clinical applications.
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