Abstract
The in vitro and in vivo stability of poly(ether urethaneurea) (PEUU) films and blood sacs with or without chemically modification by poly(dimethyl siloxane) (PDMS) has been investigated, respectively. Gel permeation chromatography (GPC) experiments showed an increase in average molecular weight for both films hydrated in saline solution at 37°C and the blood sacs utilized in electric total artificial hearts implanted in calves duo to the possible leaching of low molecular weight species and the chain extensions of residual free isocyanate groups. Correspondingly, hydration and implantation displayed an increase in mechanical strength. But excessive implantation for PDMS-modified PEUU blood sacs (such as over ∼100 day implantation) still caused possible decrease in average molecular weight and mechanical strength duo to more and more chemical degradation, just as observed in PEUU blood sacs without being modified by PDMS. Dynamical mechanical analysis (DMA) showed an increasing phase separation between hard and soft segments after immersion.
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