Abstract
The Importance of Niches-Dimensionality in Regulating the Bone Marrow Hematopoietic Stem Progenitor Cells Pool
Highlights
Research in stem cell biology relies on the knowledge of the cell microenvironment in vivo, known as “stem cell niche”, where stem cells are nurtured by the niche signals
We presented that matrices stiffness and dimensionality are important biophysical signals regulating the growth of hematopoietic progenitor cells in the bone marrow stem cell pool
We found stiffer hydrogel with higher collagen concentration promote the expansion of lineage negative (Lin-) progenitor cells and Lin-Sca-1+c-kit+ (LSK) Hematopoietic stem cells (HSCs) compared to soft hydrogel
Summary
The Importance of Niches-Dimensionality in Regulating the Bone Marrow Hematopoietic Stem Progenitor Cells Pool Pan Zhang1,2, Chen Zhang1,2, Jiyang Han1,2, Xiru Liu1,2, Qishan Wang3 and Hui Yang1,2,4,* Abstract: Research in stem cell biology relies on the knowledge of the cell microenvironment in vivo, known as “stem cell niche”, where stem cells are nurtured by the niche signals.
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