Abstract
Macrophages as A Mechano-Transducer to Direct the Osteogenic Differentiation of Mesenchymal Stem Cells
Highlights
It has been widely recognized that stem cells possess the potential of osteogenic differentiation, which greatly contribute to bone repair
This demonstration has been carried out through a coculture system to investigate the effect of macrophages which subjected to cyclic stretch on the osteogenic potential of bone marrow mesenchymal stem cells (BMSCs)
A co-culture experiment was conducted to prove that macrophage is able to transduce the mechanical signals for osteogenesis of BMSCs
Summary
It has been widely recognized that stem cells possess the potential of osteogenic differentiation, which greatly contribute to bone repair. Accumulating evidences have indicated that mechanical cues are required for bone repair [1,2].
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