The implication of dynamic monitoring of α1-acid glycoprotein and high-sensitivity C-reactive protein to assess the severity of acute pancreatitis in the early stage

Abstract

Objective To explore the value of dynamic monitoring of serum α1-acid glycoprotein (α1-AGP)and high-sensitivity C-reactive protein (HsCRP) to assess the severity of acute pancreatitis in the early stage.Methods Seventy-four cases of acute pancreatitis(AP)(23 cases of severe AP and 51 cases of mild AP)at post-admission were detected dynamically for serum α1-AGP,HsCRP,and received APACHE Ⅱ scoring and enhanced CT examination.The results were comparatively analyzed.Results The changes in α1-AGP and HsCRP levels at the same time between severe group and mild group during hospitalization showed statistically significant difference (P<0.01).α1-AGP concentrations detected at 24 h after admission to assess AP severity and APACHE Ⅱ score had a better goodness of fit(P<0.01).α1-AGP and HsCRP levels detected at the 3rd day after admission and APACHE Ⅱ score had an excellent goodness of fit(P<0.01).Conclusion α1-AGP and hsCRP can be used as indicators to assess the changes in the illness conditions of the AP patients,and predict the severity of AP in the early stage well. Key words: Acute pancreatitis; α1-acid glycoprotein; C-reactive protein