Correlation between S100A12 level and the severity of acute pancreatitis and its clinical application value

Abstract

Objective To study the relationship between S100A12 level and the severity of acute pancreatitis and its clinical application value. Methods Eighty-one patients with acute pancreatitis admitted to Tongren People’s Hospital from September 2013 to September 2017 were selected, and the serum S100A12 level of them was detected by enzyme linked immunosorbent assay (ELASA). The relationship between S100A12 level and the severity of acute pancreatitis was analyzed by receiver operating characteristic (ROC) curve. Results The serum S100A12 level, C reactive protein (CRP) levels, Ranson score and acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) score of mild acute pancreatitis group and severe acute pancreatitis group were higher than those of control group (P<0.05). The serum S100A12 level, CRP level, Ranson score and APACHE Ⅱ scores of severe acute pancreatitis group were significantly higher than those of mild acute pancreatitis group, and the difference was statistical significance (P<0.05). Conclusions By comparing the 95% confidence interval of the area under the ROC curve of the subjects, it is found that the sensitivity and specificity of S100A12 as a judgment of the severity of acute pancreatitis are better than CRP level, Ranson score and APACHE Ⅱ score. The level of S100A12 has good clinical application value, and it is superior to the commonly used evaluation methods at present. Key words: S100A12; Acute pancreatitis; Severity