The Impact of Vaccination Status on the Severity of Pain Syndrome in COVID-19 Patients

Abstract

COVID-19 has a lot of different symptoms, and pain syndrome is one of them. Getting a COVID-19 vaccine cut down on illnesses with symptoms and/or high viral loads. The study's goal is to find out how bad the pain syndrome is in people who have been vaccinated against COVID-19 and people who have not been immunized. A cross-sectional observational study was done on 304 COVID-19 patients from September 2021 to April 2023. The patients' ages ranged from 18 to 65. After they gave written permission, the people who took part in the study were given an electronic form with 20 questions. The study subjects were split into 5 groups based on their vaccine status: those who had not been vaccinated, those who had been partially vaccinated (≥ 14 days after dose 1 or < 14 days after dose 2), those who had been fully vaccinated (≥ 14 days after dose 2), those who had been vaccinated after the third dose, and those who had been vaccinated after the fourth dose. All subjects, vaccinated and not vaccinated, had pain syndrome symptoms, and there were no significant differences (P>0.05). A lot of people who weren't protected (40.2% of them) reported severe pain. In the group that got the fourth dose, however, it was not found at all (0%). It was (29.7%), (38.7%), and (39.1%) in the groups that had been partly vaccinated, fully vaccinated, and given the third dose of the vaccine, in that order. In conclusion, pain syndrome was found in all COVID-19 patients. The pain was much worse in patients who had not been vaccinated, but not in those who had gotten the fourth dose of the vaccine.