The impact of TCM staging treatment on X-ray and serum alkaline phosphatase of rabbit radius fractures delayed union

Abstract

Objective To study the impact of TCM staging treatment on serum alkaline phosphatase of Rabbit radius fractures delayed union. Metheods Left radial bone defect 1 cm were created in 75 New Zealand rabbits and they were divided into 5 group: The first, the second and the third therapeutic group, model group, and delayed union group. The second therapeutic group received herb medicine two days after the operation, the first and the third therapy group received herb medicine four weeks after the operation, the model group and delayed union group received saline solution two days after the operation, and the delayed union group received local bone marrow transplantation(2ml)four weeks after the operation. Results were observed by ALP and X-ray at 4 weeks and 8 weeks after the operation. Results ALP in the second therapy group was increased significantly[(155.54±23.33)U/L]than other groups at 4 weeks after the operation(P＜0.01). ALP in the second therapy group was increased significantly than the delayed union group(P＜0.01)and the model group(P＜0.05) at 8weeks after the operation[(62.44±27.67)U/L]; ALP in the first and the third therapy group[(74.79±2.068)U/L] were significantly lower than the model group(P＜0.05), and lower than the second therapy group(P＞0.05)at 8 weeks after the operation. X-ray endoscopic scoring in the model group increased significantly than other groups(P＜0.01)4 weeks after the operation, X-ray endoscopic scoring in the second therapy group increased significantly than the first therapy group, the third therapy group and the delayed union group(P＜0.01), but no significant difference than the model group(P＞0.05)at 8 weeks after the operation. Conclusion The treatment of traditional Chinese medicine by stages can promote fracture healing. Key words: Treatment of traditional Chinese medicine by stages; Delayed union; X-ray; ALP