Abstract
Objective: to systematically evaluate the clinical efficacy of external treatment of granulomatous mastitis (including clinical efficiency and the change of mass size). Methods: the computer was used to search CNKI, Wanfang database, VIP net, CBM, PubMed and Embase, and it was used to search and select the clinical randomized controlled trials of treating granulomatous mastitis by external treatment of traditional Chinese medicine, the retrieval time limit was from the establishment of the database to December 2020, and the key words were granulomatous mastitis, external treatment of traditional Chinese medicine. After selecting literatures, extracting datas and evaluating the risk of bias included in the study, the data included in the study were analyzed by RevMan5.3 software. Results: Seven clinical randomized controlled trials were included and 600 patients met the inclusion criteria. Seven of the trials were effective observations, and four of them were tumor size observations. There were 310 cases in the experimental group and 290 cases in the control group. All the included documents were Chinese literature. The results of the study showed that the effective rate of the experimental group (combined with the external treatment of traditional Chinese medicine) for granulomatous mastitis was 95.9%, which was significantly higher than that of the control group (without the external treatment of traditional Chinese medicine). The effective rate was 82.8% [95% CI (1.02, 1.22), Z=2.41, P=0.02<0.05]. The experimental group (combined with the external treatment of traditional Chinese medicine) had a significantly higher degree of the tumor size recovery than the control group (without the external treatment of traditional Chinese medicine) [95% CI (-2.05, -1.83), Z=34.91, P<0.00001]. Conclusion: the external treatment of granulomatous mastitis had a good clinical effect. It not only improved the clinical efficiency, but also effectively reduced the size of breast mass, which was worthy of clinical promotion. However, due to the low quality of clinical trials, further verification was needed.
Highlights
[17] Li S, Chen K, Zhu L, et al Efficacy and safety of ductal lavage for non-lactational idiopathic granulomatous mastitis: A retrospective case series study[J]
至2020年12月,检索关键词为肉芽肿性乳腺炎、中医外治,筛选文献、提取资料并对纳入研究的偏倚风险进行评价。 荟萃分析采用RevMan5.3软件对纳入研究的数据进行。结果:7篇临床随机对照试验文献,600名患者符合纳入标准,7 项为有效率观察,4项为肿块大小观察,实验组310例,对照组290例,所有纳入的文献均为中文文献。研究结果显示, 实验组治疗肉芽肿性乳腺炎的有效率为95.9%,明显高于对照组有效率为82.8%[95%C(I 1.02,1.22),Z=2.41,P=0.02
该类型资料为连续型变量,此类型资料的表达形式用 每个研究的均数和标准差来表示,由于每个研究的结果变 量的量纲相同(乳房肿块最大直径、病灶最大径均用来表 示肿块大小),因此直接采用加权均数差表示效应指标。 共有4项研究涉及肿块大小这一指标,对照组120例,实验 组140例。进行异质性检验得知,I2=0%0.05, 即不能认为研究间存在异质性,采用固定效应模型。分析 结果揭示实验组对于乳房肿块大小的恢复程度优于对照 组,二者相比差异具有统计学意义[95%C(I -2.05,1.83), Z=34.91,P
Summary
[17] Li S, Chen K, Zhu L, et al Efficacy and safety of ductal lavage for non-lactational idiopathic granulomatous mastitis: A retrospective case series study[J]. 至2020年12月,检索关键词为肉芽肿性乳腺炎、中医外治,筛选文献、提取资料并对纳入研究的偏倚风险进行评价。 荟萃分析采用RevMan5.3软件对纳入研究的数据进行。结果:7篇临床随机对照试验文献,600名患者符合纳入标准,7 项为有效率观察,4项为肿块大小观察,实验组310例,对照组290例,所有纳入的文献均为中文文献。研究结果显示, 实验组治疗肉芽肿性乳腺炎的有效率为95.9%,明显高于对照组有效率为82.8%[95%C(I 1.02,1.22),Z=2.41,P=0.02
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