The Impact of Race on Short-term Treatment Response to Bevacizumab in Diabetic Macular Edema

Abstract

To determine the impact of race and ethnicity on efficacy of intravitreal bevacizumab for diabetic macular edema in anti-vascular endothelial growth factor (VEGF) treatment-naive patients. Retrospective cohort study. Setting: Urban-based academic institution with affiliated private offices. Intravitreal anti-VEGF naïve patients seen between 2010 and 2019 of White (W) race, Black (B) race, or Hispanic (H) ethnicity aged 18 years and older with diabetic macular edema who received intravitreal injections of bevacizumab. Exclusion criteria were prior intravitreal anti-VEGF treatment, invasive ophthalmologic interventions, and laser treatments within 3months prior to first injection through the duration of the study. Exposures: Intravitreal bevacizumab. Percentage of patients with visual acuity (VA) improvement and mean percentage reduction in central macular thickness (CMT). Percentage with VA improvement was 27% vs 39% vs 50% after 1 injection (n= 314), and 34% vs 55% vs 59% after 3 injections (n= 150) for B, H, and W cohorts, respectively. Black patients experienced lower odds of VA improvement compared with White and Hispanic patients after 1 injection (odds of 0.480, CI 0.284-0.814, P= .006) and 3 injections (odds of 0.342, CI 0.149-0.782, P= .008) while controlling for age, sex, baseline glycated hemoglobin (HbA1c), baseline CMT, baseline VA, laser history, injection time course, and follow-up delay. Black patients had a significantly lower likelihood of visual acuity improvement following intravitreal bevacizumab treatment compared with White and Hispanic patients. Further research is warranted to understand the effect of race and ethnicity on anti-VEGF efficacy to ensure optimal treatment for each individual.