Abstract
562 Background: Preoperative breast biopsy might cause disaggregation of tumour cells and tumour cell spread. The purpose of this study was to investigate the impact of preoperative biopsy on the rate of metastases to the sentinel lymph node (SLN) of patients with primary breast cancer. Methods: We report the results of 2502 patients with primary breast cancer who were operated and a sentinel node biopsy was performed. The association of preoperative biopsy with the risk of SLN metastases was examined by regression analyses and tested for possible confounding well known factors for axillary node metastases. Results: 1892 Patients were available for final analyses. 1048 (55.4%) patients had a preoperative diagnosis done by fine needle aspiration or core biopsy. 642 (33.9%) patients had a positive SLN when conventional H&E and IHC staining was performed. Patients with preoperative breast biopsy showed a 1.37 fold (95% CI, 1.13–1.66) increased relative risk for SLN metastases on univariate analysis but this result was not persistent when analysis was adjusted for other relevant factors for axillary node metastases RR 1.06 (95% CI, 0.83–1.34). In addition, subgroup analyses of the risk for occult micro metastases to the SLN (detected by IHC only) on H&E negative cases, did as well not reveal an accessory risk for preoperative biopsy RR 1.04 (95% CI, 0.67–1.60). Conclusions: The conclusion of the present data is that preoperative breast biopsy does not cause artificial tumour cell spread to the SLN with possible impact on the natural history of breast cancer. An update will be presented. No significant financial relationships to disclose.
Published Version
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