The impact of positive thyroid peroxidase antibody in patients with unexplained recurrent miscarriage

Abstract

BackgroundMiscarriage is considered the most common adverse outcome in early pregnancy. Thyroid auto antibodies are involved in both these areas and are associated with major alterations in the course of pregnancy affecting the mother, the fetus, and the neonate.MethodsThe present study included 140 women who were already diagnosed with recurrent miscarriage. Following complete clinical workup, including history, examination and investigations, enrolled women were classified into two main subgroups, explained group (<italic>n</italic> = 85) and unexplained group (<italic>n</italic> = 55). Then they were classified according to Thyroid peroxidase antibody: positively group (n=28) and negatively group (n=112) and then they are treated with thyroxine and follow up for 14 weeks.ResultsRecurrent miscarriage rate increased in women with positive anti-phospholipids where Women with only Anti-APS antibody positive results accounted for 72 (51.4%). Where the remaining represent the other causes such as bicornuate uterus and thyroid abnormality. Thyroid peroxidase antibody represent important cause of abortion, in addition successful pregnancy was encountered in 26 out of 28 women treated with low doses thyroxin accounting for 92.9% successful rate; however, there was no significant difference in successful pregnancy rate between explained and unexplained groups, 9 (81.8%) versus 17 (100.0%), respectively.Women with positive thyroid peroxidase antibody can be mean cause of pregnant loss and treatment with thyroxine can lead to increasing the live-birth rate in recurrent miscarriage women with positive thyroid peroxidase antibody.