Abstract
The relationship between chronic lymphocytic thyroiditis (CLT) and breast cancer was still unclear. We investigated the positivity of thyroid peroxidase antibody (TPO-ab), thyroglobulin antibody (TG-ab), and thyrotropin receptor antibody (TSHR-ab) in 362 patients with breast cancer, 360 patients with benign breast diseases, and 386 healthy controls. Further, we analyzed the associations between TPO-ab, TG-ab, TSHR-ab, and clinical characteristics in coastal residents with breast cancer according to molecular subtype. There were no significant differences in the levels of free triiodothyronine (FT3), free tetraiodothyronine (FT4), thyroid-stimulating hormone (TSH), and the positive rates of TG-ab and TSHR-ab among three groups. The positive rate of TPO-ab in patients with breast cancer was higher compared to patients with benign breast diseases and healthy controls (P=0.002). Axillary lymph node metastasis (ALNM) in breast cancer patients with positive TPO-ab was less frequent than breast cancer patients with negative TPO-ab (P=0.022). The percentage of TNM stage I–II patients with positive TPO-ab were higher than that in patients with negative TPO-ab (P= 0.029). TPO-ab was a predictor for low prevalence of ALNM in breast cancer patients with luminal A subtype (P=0.013) and luminal B subtype (P=0.024), but not for breast cancer patients with HER2 over-expression subtype (P=0.381) and basal-like subtype (P=0.282). Thyroid peroxidase antibody was an independent predictor for the low prevalence of axillary lymph node metastasis in breast cancer patients with luminal A subtype and luminal B subtype.
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