The impact of lipid in atherosclerosis and heart failure in the east of Algeria

Abstract

In the east of Algeria, the rate of atherosclerosis is very high, unfortunately the pathological and radiology are not sufficient for evaluation and confirmation of the diagnosis. Today atherosclerosis is considered a complex pathology at the crossroads of lipid, oxidative and inflammatory alterations. Its development is caused by an immune response leading to the retention of cholesterol-rich lipoproteins in the arterial wall. Improving living conditions can have a negative influence on this pathology, such as a sedentary lifestyle, greater accessibility to a diet rich in fat, but it's not just that, there are also genetic factors. The objective of this study was to determine the impact of lipid in patients with atherosclerosis in Algerian patients and the influence of certain modifiable and non-modifiable risk factors. This is a prospective study that describes the epidemiological, diagnostic and therapeutic aspects in 50 patients, in the cardiology department of CHU Constantine during the year 2020-2021. The results of our study indicate that Atherosclerosis is frequent attack, which develops with age, behaviors related to healthy living risk factors for the disease may explain part of the cause These factors cause disturbances in the lipid profile (LDL-c and HDL-c levels and triglycerides); these in turn increase the risk of atherosclerosis. All subjects with atherosclerosis present with dyslipidemia; with very high LDL-c concentrations averaging 2.12g / l in men and 2.08g / l in women. Very high triglyceride levels on average 1.88g / l in men and 2.87g / l in women. Reduced HDL-c concentrations averaging 0.2g / l in both sexes and elevated total cholesterol concentrations averaging 3.6g / l averaging in men and 3.25g / l in women. There was a highly significant correlation between increased concentration of LDL cholesterol and HDL LDL triglycerides and the development of atherosclerosis.