The impact of LEEP knife treatment of cervical intraepithelial neoplasia on pregnancy and delivery mode

Abstract

Objective A retrospective analysis was conducted to explore the impact of LEEP knife treatment of cervical intraepithelial neoplasia (CIN) on women's pregnancy outcomes and modes of delivery.Methods Fifty-eight women were recruited as the experimental group from our hospital.They accepted LEEP surgery for treatment of CIN during 2009 and became pregnant before December 2011.Sixty pregnant women without history of LEEP surgery were randomly selected as the control group from January 2010 to December 2011.A retrospective analysis of the study groups was conducted to investigate the pregnancy situations,two-wire receiver modes of delivery and pregnancy outcome of participants.Results There was no significant difference between the two groups on rates of abortion,vaginal delivery and cesarean section (P ＞ 0.05).The experimental group had significantly higher rates of preterm birth than control group (12.07％ vs.1.67％,x2 =5.049,P ＜ 0.05).No significant difference was observed between the two groups on rates of premature rupture of membranes,cervical laceration,postpartum hemorrhage,low birth weight and neonatal asphyxia(P ＞ 0.05).Conclusion LEEP knife treatment of CIN has no significant effect on mode of delivery or pregnancy outcome,but may increase the incidence of preterm birth.Management of pregnant women with history of CIN and LEEP surgery should be strengthened. Key words: LEEP surgery; Cervical intraepithelial neoplasia; Mode of delivery; Pregnancy outcome