Abstract
Colorectal cancer (CRC) is one of the most familial of all malignancies. Adenomatous polyps, the precursors of most CRCs, segregate with colon cancer in families and are found in excess in relatives of those with CRC.1 The screening colonoscopy study by Tsai and Strum in this issue failed to find a statistically significant increased risk of advanced adenomas in persons with a first-degree relative with CRC compared to persons with no family history of CRC.2 The results should be viewed with caution, however, in view of some of the subject exclusion criteria applied. Use of these criteria may also explain why the results of this study are at variance with similar studies that do demonstrate an excess of colonic neoplasia when a family history of CRC is present.
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