Abstract
This review mainly focuses on the role of circadian rhythm in both causation and treatment of bipolar disorder (BD). Circadian rhythm is an essential modulator that makes our body function in tune with the 24-h cycle, controlling the metabolic and endocrine processes. In terms of the causation and the development of BD, disrupted circadian rhythms might play a crucial part. It would be discussed from the dysregulation of neurotransmitters such as dopamine, serotonin, norepinephrine and melatonin, which are modulated by the clock and contribute to BD. The clock genes like Circadian locomotor output cycles kaput (CLOCK), Period (PER), and Cryptochrome will also be discussed, since their expressions operate the clock and their polymorphisms could lead to abnormal circadian rhythm and make people present certain symptoms. Furthermore, it can be inferred that regulating circadian rhythm might be an efficacious treatment for BD, including the administration of lithium and light therapy, both of which target regulating circadian rhythm by modulating the elements of the clock.
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