The Impact of Aloe Vera Gel on Healing of Surgically Made Maxillary Mucosal Wounds in Rabbits

Abstract

Objective: The purpose of present study is to evaluate the effect of Aloe Vera gel on granulation tissue formation and angiogenesis and re-epithelialization stages of experimental healing process of maxillary oral mucosa in rabbits. Materials and methods: The current experimental study was carried out on twenty albino rabbits which were randomly selected and inhabited under same conditions involving ventilation, temperature and diet. Each rabbit was anesthetized separately and undergone surgical procedure in both sides of upper alveolar bone included longitudinal oral mucosal incision followed by circular bone defect creation, then placement of tiny gel foam piece and Aloe Vera gel in left side, while right side bone hole was l eft empty to act as control. According to euthanization time, rabbits were divided into five groups and sacrificed at the 3rd, 7th, 14th,28th and 42 days post-wounding, histological and histomorphometrical assessment included evaluation of am ount of granulation tissue formed and angiogenesis and re-epithelialization. Results: Histological results revealed a statistically significant difference in amount of granulation tissue and neo-vascularization formed and re-epithelialization between control and Aloe Ver a groups at certain time intervals within total period of experiment with favor to Aloe Vera group. Conclusion: The us e of Aloe Vera gel exhibits a beneficial effect by increasing granulation tissue formation and subsequent angi ogenesis and enhancement of re-epithelialization in healing process.