Abstract
Stem cell-based regenerative therapies hold great promises to treat a wide spectrum of diseases. However, stem cell engraftment and survival are still challenging due to an unfavorable transplantation environment. Advanced glycation end-products (AGEs) can contribute to the generation of these harmful conditions. AGEs are a heterogeneous group of glycated products, nonenzymatically formed when proteins and/or lipids become glycated and oxidized. Our typical Western diet as well as cigarettes contain high AGEs content. AGEs are also endogenously formed in our body and accumulate with senescence and in pathological situations. Whether AGEs have an impact on stem cell viability in regenerative medicine remains unclear, and research on the effect of AGEs on stem cell proliferation and apoptosis is still ongoing. Therefore, this systematic review provides a clear overview of the effects of glycated proteins on cell viability in various types of primary isolated stem cells used in regenerative medicine.
Highlights
Regenerative therapies, including stem cell treatments, hold a high potential for treating patients with a spectrum of diseases
Articles were excluded based on different criteria: (1) articles with Advanced glycation end-products (AGEs), receptor for AGEs (RAGE), or stem cells as outcome measurements; (2) effects on other cell types than stem cells or progenitor cells; (3) articles about RAGE or diabetes and not AGEs; (4) articles with AGEs used as a diabetic model; (5) reviews; (6) book chapters; (7) announcements; (8) retracted papers; and (9) articles written in other languages than English. 75 full-text articles were assessed for eligibility
The electronic databases PubMed and Web of Science were used to identify all articles regarding the impact of AGEs on primary stem cell proliferation and apoptosis
Summary
Regenerative therapies, including stem cell treatments, hold a high potential for treating patients with a spectrum of diseases. Stem cells are defined as undifferentiated cells with unlimited self-renewing capacity They have the potential to form identical clones throughout the symmetrical division but can differentiate into multiple cell types depending on the stem cell potency [1]. Blood-derived stem cells (BDSCs) are used in the clinic to restore the hematopoietic system in the blood and bone marrow malignancies or in autoimmune diseases [11]. Despite their promising paracrine effects, differentiation, and migration capacities for repairing injured tissue, transplantation of stem cells remains challenging due to low cell engraftment, low cell survival, and suboptimal transplantation conditions [12]
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