The Immunomorphological condition placentae of the women connected with tobacco smoking

Abstract

Immunomorphological, histologic research with application of semi-thin cuts bioptats placentae of the women connected with tobacco smoking to pregnancy, during all pregnancy and in the I trimester of pregnancy is carried out. Immunomorphological researches of placentae of studied groups showed that the greatest percent of the revealed fixed pathogenic immune complexes (PEAK) including existence fibrinogen, C3 fraction of a compliment, antibodies and pro-inflammatory citokins, were observed in group of women which smoked all pregnancy. The smallest percent of identification PEAK was in a placenta of the women, stopped to smoke to pregnancy. By parallel kliniko-laboratory comparison it is established that the greatest frequency of complications of pregnancy is observed at women who smoked all pregnancy. At histologic research of placentae of women of studied groups in the field of adjournment the PEAK is observed tsirkulyatorno-dystrophic and necrotic processes. The most widespread changes of a placenta are found at the smokers which pregnancy became complicated the gestozy. In the field of adjournment the PEAK leads damages of membrane structures of a placentary barrier to destructive changes of a placenta, to development of immunopathological process with violation of an immune homeostasis and to development of placentary insufficiency that is adversely reflected in an outcome of pregnancy and childbirth, and also on a fruit and newborn condition.