Abstract
Aim. To study the features of the hormonal function of the placenta in women with insulin resistance. Material and methods. To study the hormonal function of the placenta of women with insulin resistance, 86 pregnant women in the third trimester of pregnancy were tested for the insulin resistance index (HOMA index), and the level of hormones in the blood. Group I of women (main) consisted of 30 pregnant women with risk factors for diabetes mellitus with an IRI above 2,84. Group II included 26 women of the same group, but with an IRI below 2,84. Group III (control) – 30 healthy women. Results and discussion. With insulin resistance, the average level of hormones such as progesterone, placental lactogen, estradiol decreases, which indicates an unfavorable course of pregnancy and perinatal outcomes as a result of such a complication as placental insufficiency. Conclusion. The study of the features of the development of placental insufficiency under the influence of various risk factors will allow for timely prevention and treatment of this pathology, which will improve perinatal outcomes in women with insulin resistance. IR contributes to the metabolic needs of the fetus and is the result of circulating placental hormones.
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