Abstract
Background & objectiveHelicobacter pylori (H. pylori) is one of the most important pathogenic bacteria cause stomach cancer. The present study aimed to evaluate Cluster of Differentiation 4 (CD4+) and Cluster of Differentiation 8 (CD8+) in patients infected with stomach cancer caused by H. pylori. A total of 79 individuals (male and female) 18 to 60 years old have been included in this study; 30 healthy individuals as control, 29 patients infected with H. pylori and 20 stomach cancer patients infected H. pylori. Materials & methodsCD4+ and CD8+ have been measured in serum of all 79 individuals using Enzyme linked immunosorbent assay technique. ResultsThere was significant increase (P-value < 0.05) in serum concentration of CD4+ and CD8+ in stomach cancer patients infected with H. pylori as compared with healthy individuals. The same result has been detected in stomach cancer patients infected with H. pylori as compared with patients infected with H. pylori only. While, there was no significant differences between serum concentration of CD8+ in stomach cancer patients infected with H. pylori and patients infected with H. pylori only. ConclusionsCD4+ and CD8+ can be considered as a good markers as early diagnosis in of stomach cancer caused by H. pylori.
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