Abstract
The aim of the experiment was to study the immunohistochemical reaction the periodontal tissues regenerated by nano biphasic calcium phosphate bioceramics (NBCP). Two lateral third incisors were randomly selected and operated as experimental group in two beagle dogs. As control the contralateral third incisors of the same jaw were done nothing. In experimental group, alveolar bone defects were made surgically at the labial aspects of the teeth. After root conditioning, the defects were filled with NBCP. 16 weeks after operation, the dogs were killed. The immunohistochemistry examination was used to observe the newly formed periodontium in the experimental group and the normal periodontium in the control group. The positive expressions of osteocalcin (OCN) in newly formed periodontium were the same to that in normal periodontal tissues.
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