Abstract
B7-H6 is a new immune checkpoint molecule related to B7 family; however, little research has been performed to determine its expression among tumors. In this study, we investigated the immunohistochemical expression of B7-H6 protein in 141 biopsy proven oral squamous cell carcinoma tissues. The specimens were subjected for immunohistochemical analysis to evaluated B7-H6 expression and was graded according to the intensity of cytoplasm and membrane staining. The distribution of B7-H6 expression was also correlated with different clinicopathological parameters of oral squamous cell carcinoma.Overall, 69 out of 141 oral squamous cell carcinoma cases had shown the expression of B7-H6 protein, majority of which belongs to moderately differentiated histological grade. This accounts for strong statistical association of B7-H6 with oral squamous cell carcinoma (P-value=0.001). The distribution of B7-H6 was also observed across broad range of clinicopathological characteristics of disease, however only long term naswar consumers have shown significant statistical difference with B7-H6 expression. We thus conclude that, B7-H6 may represent a new marker for oral squamous cell carcinoma with potential to forecast biological aggressiveness of oral squamous cell carcinoma. Hence, B7-H6 may serve as an immune target for oral squamous cell carcinoma therapy, which needs to evaluated in future studies.
Highlights
The incidence of oral cancer is increasing across the globe
We investigated the immunohistochemical expression of B7-H6 protein in 141 biopsy proven oral squamous cell carcinoma tissues
B7-H6 may serve as an immune target for oral squamous cell carcinoma therapy, which needs to evaluated in future studies
Summary
The incidence of oral cancer is increasing across the globe. This rise in incidence is more pronounced in developing countries like India, Pakistan, Sri Lanka, and Bangladesh; largely contributed by bad habits which includes; use of addictive chemicals and cigarette smoking.[1,2] Squamous cell carcinoma accounts for 90% of all oral cancer.[3]. The immune system is fundamental part of cancer etiology which under covers expression of tumor specific aberrant antigens; that aids in cancer cell survival by escaping immunological surveillance.[6] B7 family of protein has a major role in this regard. B7 family regulates balance between the suppression of auto immunity and regulates immune response to antigens.[7] B7 family represent several cell surface protein which are structurally related and includes; B7-1, B7-2, B7-H1, B7-DC, B7H2, B7-H3, B7-H4 and B7-H6.[8]
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