Abstract
The immune status of lethally irradiated mice treated with isologous, homologous, or heterologous rat bone marrow was studied by injecting sheep or rat RBC antigens into the protected mice 200 to 300 days after treatment. The results showed the foreign bone marrow-protected mice to have a subnormal immune mechanism, provided that the foreign transplant persisted in these animals, whereas the isologously treated mice responded in a normal manner. Two postulates are considered in the interpretation of this subnormal immune mechanism: the lowered immune response is a quantitative expression of the functional antibody tissue remaining in these mice after recovery from the foreign bone marrow reaction, or that an in vivo antigenantibody reaction persists in these animals and consequently affects their ability to respond normally to other antigens. Emphasis is placed on a re-evaluation of the concept of tolerance as applied to the long-term survivors of the foreign marrow- protected mice. (auth)
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