Abstract
Poly lactic acid (PLA) has been commercialized as guided bone regeneration membranes. However, PLA membranes are associated with their inherent shortcomings such as insufficient osteoinductive ability. Herein, a cyclo-trimer of acetonitrile (CTA) was covalently immobilized onto PLA films, which would combine the bioactive functions of CTA and good degradability of PLA. The immobilization of CTA enhanced the initial attachment, cell viability, and osteogenic differentiation of osteoblast-like cells. The BMP-SMAD signaling pathway may be involved in the enhancement of osteoinductive capacity of CTA immobilized PLA films. Overall, PLA-CTA films shows a potential for guided bone regeneration.
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