Abstract
THE USE of the weight of the immature uterus in the assay of gonadotropic substances has been established by Levin and Tyndale (I) employing mice, and by Heller, Lauson and Sevringhaus (2) using rats. Studies on the mechanism of the uterine reaction led the present authors to investigate the possibility of a similar assay for estrogens. Aportion of this study has been briefly reported previously (3). It is the purpose of thispaper to discuss in detail the method of assay and the tests made of its utility. Female albino rats of the Sprague-Dawley strain, 22 to 23 days old and 34 to 39 gm. inweight, were used in all the experiments. Aqueous solutions of crystalline estradiol, estrone and estriol3 were injected subcutaneously twice daily for 3 days. One'half cc. was given at each injection. On the morning of the fourth day
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