Abstract
A growing body of literature suggests that cytokines can play an important role in chronic insomnia disorder (CID); however, the underlying mechanisms are still unknown. Here we show that serum levels of pro-inflammatory mediators including IL-12, IFN-γ and ICAM-1 are elevated in CID group when compared with healthy controls, and that the REM sleep duration diminishes with increased concentrations of IL-12 and IFN-γ in individuals with CID. Furthermore, we find that lowered serum concentration of IL-1ra is negatively correlated with severity of insomnia in CID group. These data add to the evidence that the imbalance of circulating pro-inflammatory mediators IL-12, IFN-γ, and ICAM-1 and anti-inflammatory cytokine IL-1ra is important in CID pathogenesis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.