Abstract
The analyses of 99gTc-DMSA complexes prepared under alkali and acidic reactions were reported. Modern analytical, separation and spectral methods such as NMR (1H-NMR, 13C-NMR, APT, COSY and HSQC) and Q-TOF HPLC–MS/MS system with ESI were employed to determine the identity and characterization of the products. The structure of 99gTc(V)DMSA was clearly confirmed and its fragmentation path in negative and positive ionisation mode was suggested. The effect of ascorbic acid and new alternative labelling with the use of NH499gTcOCl4 was examined. Surprisingly, 99gTc(III)DMSA complex was not formed under acidic reaction conditions. 99gTc(V)DMSA complex was the main reaction product under both experimental conditions. This result suggests the key role of 99g/99mTc concentration during the process of radiopharmaceuticals preparation.
Published Version
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