Abstract
Whilst there is general agreement upon the ultrastructure of astrocytes and oligodendrocytes, characterisation of microglia in healthy adult brain has remained uncertain.Light microscopy of silver stained cat cerebral cortex revealed microglia close to neurons and blood vessels and sometimes remote from either.A similarly situated glial cell did not conform to ultrastructural criteria for macroglia; it was identified as microglia. It was often fusiform in shape and when compared with astrocytes and oligodendrocytes, at low magnification, was intermediate in density. Intervening astrocyte cytoplasm often separated microglia from neurons and blood vessels.Clumped chromatin was distributed around the periphery of the elongated nucleus. Cytoplasm was predominantly polar in distribution. Elongated endoplasmic reticulum was often oriented along the longitudinal axis of the cell; the cisternae contained material of greater density than the surrounding cytoplasmic matrix. The outer surface of the endoplasmic reticulum was irregularly studded with ribosomes.
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