Abstract
Rectal mucosal proliferation was measured in 116 individuals using the metaphase arrest technique crypt cell production rate (CCPR). CCPR was found to be significantly elevated in individuals with adenomas (n = 42, CCPR = 13 cc c-1h-1, range 7-25 Cl 10-15) compared with normals (n = 21, CCPR = 10 cc c-1h-1 range 5-24 Cl 7-11, Mann-Whitney P = 0.001 z = 3.2). Mucosal proliferation was increased among individuals who were undergoing adenoma follow up but in whom no further adenomas were found (n = 37 CCPR = 12 range 5-26 cc c-1h-1 Cl 10-14) compared to controls (Mann-Whitney P = 0.01 z = 2.4) Proliferation in vegetarians i.e. low risk (n = 16) was similar to controls. Measurement of proliferative indices in rectal mucosa by the stathmokinetic technique CCPR can discriminate between high and low risk groups for colorectal cancer.
Highlights
ObjectivesThe aim of the present study was to use measurements of crypt cell production rate (CCPR) to determine individuals who may be at an increased or decreased risk of colorectal neoplasia because of the presence of adenomas
(n=42, crypt cell production rate (CCPR)= 13ccc-lh-1, range 7-25CI 10-15) compared with normals (n=21, CCPR= lOccc-lh-1 range 5-24 Cl 7-11, Mann-Whitney P = 0.001 z = 3.2)
There is evidence suggesting that there is a link between mucosal proliferation and colorectal neoplasia (Deschner et al, 1966; Bleiberg et al, 1972; Deschner & Lipkin 1975; Deschner & Maskens 1982; Lipkin et al, 1983; Lipkin et al, 1984)
Summary
The aim of the present study was to use measurements of CCPR to determine individuals who may be at an increased or decreased risk of colorectal neoplasia because of the presence of adenomas
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