Abstract
Heterocyclic amine boranes were observed to be potent hypolipidemic agents in rodents at 8 mg kg per day lowering both serum cholesterol and triglyceride levels. These agents were also effective in lowering tissue lipids. Rat serum lipoprotein cholesterol levels were reduced in the low density lipoprotein (LDL) and very low density lipoprotein (VLDL) fractions and elevated in the high density lipoprotein (HDL) fraction after 14 days. The modes of action of the agents appear to accelerate excretion of lipids in the bile and the suppression of the activities of key hepatic regulatory enzymes of lipids synthesis.
Full Text
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call