Abstract
Abstract To date, a large body of data supports the hygiene hypothesis. However, the explanation of the relationship of autoimmune and allergic diseases with a decrease in microbial load still seems insufficient. Here, an attempt is
Highlights
To date, a large body of data supports the hygiene hypothesis
The necessity of interaction with ambient microorganisms is interpreted as the necessity of their contact with the immune system, whose insufficient stimulation leads to changes in the ratio between the Th1 and Th2 cell populations, giving rise to autoimmune and allergic disorders
It is hardly possible yet to explain the exact mechanisms of allergic and autoimmune processes caused by a decrease in microbial load; these should result from disturbance of the primary function of the immune system related to normal contacts of immune cells and receptors with self cells and tissues [2]
Summary
A large body of data supports the hygiene hypothesis. the explanation of the relationship of autoimmune and allergic diseases with a decrease in microbial load still seems insufficient. The necessity of interaction with ambient microorganisms is interpreted as the necessity of their contact with the immune system, whose insufficient stimulation leads to changes in the ratio between the Th1 and Th2 cell populations, giving rise to autoimmune and allergic disorders. There are grounds to believe that the necessity of interaction with microorganisms stems from the usefulness of microbial activities per se rather than immune stimulation [1].
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