Abstract
Summary. In some experiments on the renal function in the horizontal and erect postures the authors observed certain changes in the inulin clearance (glomerular filtration) and the diodrast clearance (renal blood flow) which, compared with the changes occurring in the erect posture in the pressure and composition of the blood (colloid osmotic pressure, cell volume and viscosity), necessitated penetrating into the problems of glomerular hydrodynamics. The hydraulic problem is the following: What laws govern the laminar flow of colloidal solutions in semi‐permeable tubes? Formulae are deduced for flow, filtration, hydraulic and colloid osmotic pressure in a semi‐permeable tube perfused by a colloidal solution. The validity of the formulae for water and plasma is proved by model experiments. The formulae are employed for calculating the results of a concrete experiment made to determine the renal function in the passive erect posture. From these calculations the authors plot the course of the hydraulic and colloid osmotic pressures in a glomerular capillary for horizontal and erect postures. The course of these curves shows that a contraction of vas efferens must take place in order that the observed simultaneous changes in the inulin and diodrast clearances and in the composition and pressure of the blood may occur.
Published Version
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