Abstract
SLC11A1 is known to link infections, autoimmunity and cancers. A review is presented of the mechanisms by which a balance is maintained between infections caused by pathogens (viral, bacterial and protozoan; intracellular and extracellular) and disorders resulting from (acute or chronic) inflammation, and of the interactions that determine how the initial innate immune system directs subsequent acquired immune responses in human populations
Highlights
SLC11A1 is known to link infections, autoimmunity and cancers
This review discusses the role of the solute carrier family 11 member 1 protein (SLC11A1), formerly NRAMP1, in linking infections, autoimmunity and cancer
Slc11a1 exacts pleiotropic effects on macrophage function that include enhanced chemokine KC, tumor necrosis factor-a, interleukin-1b, inducible nitric oxide synthase and MHC class II expression; all are important in the induction and maintenance of autoimmunity and cancer and are crucially important in resistance to intramacrophage pathogens such as tuberculosis
Summary
SLC11A1 is known to link infections, autoimmunity and cancers. A review is presented of the mechanisms by which a balance is maintained between infections caused by pathogens (viral, bacterial and protozoan; intracellular and extracellular) and disorders resulting from (acute or chronic) inflammation, and of the interactions that determine how the initial innate immune system directs subsequent acquired immune responses in human populations. Keywords SLC11A1; cancer; infections; autoimmunity; chronic inflammation; ATF/CREB.
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