Abstract
The molecular mechanisms of chronic inflammation development
Highlights
Inflammation is critical for the development of many complex diseases and disorders including autoimmune diseases, metabolic syndrome, neurodegenerative diseases, cancers, and cardiovascular diseases
Inflammation comes in two types: chronic inflammation, which can be defined as a dysregulated form of inflammation, and acute inflammation, which can defined as a regulated form
The authors focus a TLR4 ligand, lipid A, produced by Gram-negative bacteria and its variants to investigate how these compounds induce acute and chronic inflammation (Chilton et al, 2012) and post-ischemic inflammation in the brain induced by endogenous TLR ligands, high mobility group box 1 (HMGB1), and peroxiredoxin family proteins (Shichita et al, 2012)
Summary
Inflammation is critical for the development of many complex diseases and disorders including autoimmune diseases, metabolic syndrome, neurodegenerative diseases, cancers, and cardiovascular diseases. The first (Chilton et al, 2012) and second articles (Shichita et al, 2012) present the roles of TLR-mediated signals in chronic inflammation. They proposed that an altered metabolism in the cardiovascular system initially induced by macrophages and innate immunity can fuel chronic inflammation and subsequent migration of antigen-non-specific activated T cells to the affected site.
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