Abstract
The human phylome, which includes evolutionary relationships of all human proteins and their homologs among thirty-nine fully sequenced eukaryotes, is reconstructed.
Highlights
Phylogenomics analyses serve to establish evolutionary relationships among organisms and their genes
We have initially applied this pipeline to the human genome
Our results indicate that there is a great topological diversity affecting the three unresolved scenarios that we have discussed
Summary
Phylogenomics analyses serve to establish evolutionary relationships among organisms and their genes. A number of genome wide experimental and computational analyses have been performed that capture different aspects of the biology of the human cell These analyses include, among many others, those of the so-called transcriptome [3], proteome [4], interactome [5] and metabolome [6]. The availability of such large datasets have added new dimensions to the study of the human organism; are they useful in elucidating the function of otherwise uncharacterized proteins, but they provide information on the system-level properties of the cell [7].
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