Abstract
To determine whether enhanced radiosensitization within a host component (tumor blood vessels or stroma) improves tumor control and to determine whether DNA-PK inhibition is a molecular target for drug development. DNA dependent protein kinase (DNA-PK) is crucial to the rapid repair of DNA double strand breaks induced by ionizing radiation. DNA-PK is a heterotrimer composed of two binding subunits (Ku80, Ku70) and the DNA-PK catalytic subunit (DNA-PKcs). In SCID mice, DNA-PKcs has a truncated C-terminus and was therefore used as a DNA-PK knockout for in vivo studies of tumor response.
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